In one of the most important advances in modern medicine, a team of investigators isolated and purified insulin in a building that stood on this site. On May 17, 1921, Frederick Banting, a young surgeon, and Charles Best, a recent graduate in physiology and biochemistry, began a series of experiments on pancreatic secretions in an attempt to find a treatment for "diabetes mellitus." Working under the general direction of J.J.R. Macleod, an expert in carbohydrate metabolism, they developed a promising anti-diabetic extract. James Collip, a noted biochemist, then increased the purity and potency of the substance. With the first successful clinical test of insulin on a human diabetic on January 23, 1922, Banting, Best, Macleod and Collip ensured prolonged lives for millions of diabetics throughout the world.

Location

In front of the Medical Sciences Building, the site of the former building in which the discovery was announced, 1 King's College Circle, University of Toronto, Toronto

Themes

• Scientific and technological innovations